IN VIVO ACTIVITY OF TUMOR NECROSIS FACTOR (TNF) MUTANTS: Secretory but Not Membrane-Bound TNF Mediates the Regression of Retrovirally Transduced Murine Tumor

We have previously demonstrated that murine tumor cells transduced with a retrovirus containing the cDNA encoding wild-type human TNF regress in vivo when injected into immunocompetent mice; this regression is T cell mediated. To determine whether membrane-associated or secreted TNF was responsible...

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Main Authors: KARP, STEPHEN E., HWU, PATRICK, FARBER, ALIK, RESTIFO, NICHOLAS P., KRIEGLER, MICHAEL, MULÉ, JAMES J., ROSENBERG, STEVEN A.
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2121327/
https://ncbi.nlm.nih.gov/pubmed/1517571
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