Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

The prohormone convertase SPC2 (PC2) participates in the processing of proinsulin, proglucagon, and a variety of other neuroendocrine precursors, acting either alone or in conjunction with the structurally related dense-core granule convertase SPC3 (PC3/PC1). We have generated a strain of mice lacki...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Furuta, Machi, Yano, Hideki, Zhou, An, Rouillé, Yves, Holst, Jens J., Carroll, Raymond, Ravazzola, Mariella, Orci, Lelio, Furuta, Hiroto, Steiner, Donald F.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1997
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192619/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6646
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