Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

The prohormone convertase SPC2 (PC2) participates in the processing of proinsulin, proglucagon, and a variety of other neuroendocrine precursors, acting either alone or in conjunction with the structurally related dense-core granule convertase SPC3 (PC3/PC1). We have generated a strain of mice lacki...

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Detalhes bibliográficos
Main Authors: Furuta, Machi, Yano, Hideki, Zhou, An, Rouillé, Yves, Holst, Jens J., Carroll, Raymond, Ravazzola, Mariella, Orci, Lelio, Furuta, Hiroto, Steiner, Donald F.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21212/
https://ncbi.nlm.nih.gov/pubmed/9192619
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