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Chromosome architecture can dictate site-specific initiation of DNA replication in Xenopus egg extracts
Xenopus egg extracts initiate DNA replication specifically at the dihydrofolate reductase (DHFR) origin locus with intact nuclei from late G1-phase CHO cells as a substrate, but at nonspecific sites when purified DNA is assembled by the extract into an embryonic nuclear structure. Here we show that...
Uloženo v:
| Médium: | Artigo |
|---|---|
| Jazyk: | Inglês |
| Vydáno: |
The Rockefeller University Press
1996
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2121087/ https://ncbi.nlm.nih.gov/pubmed/8947545 |
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