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Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells

An overactive renin-angiotensin-aldosterone system (RAAS) has a central role in the pathogenesis of hypertension and cardiac hypertrophy, precursors of cardiac failure. Natriuretic peptides and NO acting through their second messenger, cGMP, increase natriuresis and diuresis, and inhibit renin relea...

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Hlavní autoři: Gambaryan, Stepan, Wagner, Charlotte, Smolenski, Albert, Walter, Ulrich, Poller, Wolfgang, Haase, Winfried, Kurtz, Armin, Lohmann, Suzanne M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21192/
https://ncbi.nlm.nih.gov/pubmed/9671794
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