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CD4(+)CD25(−)Foxp3(−) Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis

Nonhealing forms of leishmaniasis in humans are commonly associated with elevated levels of the deactivating cytokine IL-10, and in the mouse, normally chronic infections can be cleared in the absence of IL-10. Using a Leishmania major strain that produces nonhealing dermal lesions in a T helper typ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Anderson, Charles F., Oukka, Mohammed, Kuchroo, Vijay J., Sacks, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118728/
https://ncbi.nlm.nih.gov/pubmed/17283207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061886
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