All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

We demonstrate that all-trans retinoic acid (RA) induces FoxP3(+) adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype (α4β7(+) CC chemokine receptor 9(+)) and the capacity to home to the lamina propria of the small intestine. Under conditions that favor the differentiation of A-T...

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Bibliografiske detaljer
Main Authors: Benson, Micah J., Pino-Lagos, Karina, Rosemblatt, Mario, Noelle, Randolph J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2007
Fag:
Brief Definitive Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118687/
https://ncbi.nlm.nih.gov/pubmed/17620363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070719
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