Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1–transformed acute lymphoblastic leukemia cells

The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. ALL cells are derived from B cell precursors in most cases and typically carry rearranged immunoglobulin heavy chain (IGH) variabl...

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Main Authors: Feldhahn, Niklas, Henke, Nadine, Melchior, Kai, Duy, Cihangir, Soh, Bonaventure Ndikung, Klein, Florian, von Levetzow, Gregor, Giebel, Bernd, Li, Aihong, Hofmann, Wolf-Karsten, Jumaa, Hassan, Müschen, Markus
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2007
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118573/
https://ncbi.nlm.nih.gov/pubmed/17485517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062662
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