AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) class switch recombination and somatic hypermutation, and has also been implicated in translocations between Ig switch regions and c-Myc in plasma cell tumors in mice. We asked if AID is required for accelerated tumor de...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kovalchuk, Alexander L., duBois, Wendy, Mushinski, Elizabeth, McNeil, Nicole E., Hirt, Carsten, Qi, Chen-Feng, Li, Zhaoyang, Janz, Siegfried, Honjo, Tasuku, Muramatsu, Masamichi, Ried, Thomas, Behrens, Timothy, Potter, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118515/
https://ncbi.nlm.nih.gov/pubmed/17998390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070882
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares