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Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C
Activated protein C (APC) reduces mortality of severe sepsis patients but increases the risk of serious bleeding. APC exerts anticoagulant activity by proteolysis of factors Va/VIIIa. APC also exerts antiinflammatory and antiapoptotic effects and stabilizes endothelial barrier function by APC-initia...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118455/ https://ncbi.nlm.nih.gov/pubmed/17893198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070404 |
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