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Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy

Divergent hypotheses exist to explain how signaling by the B cell receptor (BCR) is initiated after antigen binding and how it is qualitatively altered in anergic B cells to selectively uncouple from nuclear factor κB and c-Jun N-terminal kinase pathways while continuing to activate extracellular si...

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Autors principals: Bléry, Mathieu, Tze, Lina, Miosge, Lisa A., Jun, Jesse E., Goodnow, Christopher C.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118358/
https://ncbi.nlm.nih.gov/pubmed/16801401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060552
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