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Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
The expression of self-antigen in the thymus is believed to be responsible for the deletion of autoreactive T lymphocytes, a critical process in the maintenance of unresponsiveness to self. The Autoimmune regulator (Aire) gene, which is defective in the disorder autoimmune polyglandular syndrome typ...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118158/ https://ncbi.nlm.nih.gov/pubmed/17116738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061864 |
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