IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

Aberrant cytokine expression has been proposed as an underlying cause of psoriasis, although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in human psoriasis and may be a master regulator cytokine. Direct intradermal administration of IL-23 in mouse skin, but no...

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Autors principals: Chan, Jason R., Blumenschein, Wendy, Murphy, Erin, Diveu, Caroline, Wiekowski, Maria, Abbondanzo, Susan, Lucian, Linda, Geissler, Richard, Brodie, Scott, Kimball, Alexa B., Gorman, Daniel M., Smith, Kathleen, de Waal Malefyt, Rene, Kastelein, Robert A., McClanahan, Terrill K., Bowman, Edward P.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118145/
https://ncbi.nlm.nih.gov/pubmed/17074928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060244
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