Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenecity of human platelets

Tissue factor (TF) is an essential cofactor for the activation of blood coagulation in vivo. We now report that quiescent human platelets express TF pre-mRNA and, in response to activation, splice this intronic-rich message into mature mRNA. Splicing of TF pre-mRNA is associated with increased TF pr...

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Autors principals: Schwertz, Hansjörg, Tolley, Neal D., Foulks, Jason M., Denis, Melvin M., Risenmay, Ben W., Buerke, Michael, Tilley, Rachel E., Rondina, Matthew T., Harris, Estelle M., Kraiss, Larry W., Mackman, Nigel, Zimmerman, Guy A., Weyrich, Andrew S.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
Matèries:
Brief Definitive Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118136/
https://ncbi.nlm.nih.gov/pubmed/17060476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061302
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