Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells

Expression of peroxisome proliferator-activated receptor α (PPARα) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARα/retinoid x receptor liga...

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Main Authors: Zhou, Yan-Ting, Shimabukuro, Michio, Wang, May-Yun, Lee, Young, Higa, Moritake, Milburn, Joseph L., Newgard, Christopher B., Unger, Roger H.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC21174/
https://ncbi.nlm.nih.gov/pubmed/9671776
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