Alpha‐1‐antitrypsin deficiency: optimal therapeutic regimen based on population pharmacokinetics

BACKGROUND: Exogenous doses of 60 mg/kg α(1)‐antitrypsin (AAT) every 7 days are recommended in patients with severe AAT deficiency. However, long term administration of weekly doses is not well accepted by patients. Using pharmacokinetic simulations, we evaluated whether steady state minimum concent...

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Detaylı Bibliyografya
Asıl Yazarlar: Soy, D, de la Roza, C, Lara, B, Esquinas, C, Torres, A, Miravitlles, M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMJ Group 2006
Konular:
Alpha-1-Antitrypsin Deficiency
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117047/
https://ncbi.nlm.nih.gov/pubmed/16928711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2005.057943
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