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Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast
BiP/GRP78 is an essential member of the HSP70 family that resides in the lumen of the endoplasmic reticulum. In yeast, BiP/GRP78 is encoded by the KAR2 gene. A temperature sensitive mutation was isolated in KAR2 and found to cause a rapid block in protein secretion. Secretory precursors of a number...
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| Formato: | Artigo |
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| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1990
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2116122/ https://ncbi.nlm.nih.gov/pubmed/2190988 |
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