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Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase is anchored to the endoplasmic reticulum (ER) membrane by a hydrophobic NH2- terminal domain that contains seven apparent membrane-spanning regions and a single N-linked carbohydrate chain. The catalytic domain, which includes the COOH-termin...

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Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1987
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2114504/
https://ncbi.nlm.nih.gov/pubmed/3584246
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