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Motif module map reveals enforcement of aging by continual NF-κB activity

Aging is characterized by specific alterations in gene expression, but their underlying mechanisms and functional consequences are not well understood. Here we develop a systematic approach to identify combinatorial cis-regulatory motifs that drive age-dependent gene expression across different tiss...

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Detalhes bibliográficos
Principais autores: Adler, Adam S., Sinha, Saurabh, Kawahara, Tiara L.A., Zhang, Jennifer Y., Segal, Eran, Chang, Howard Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2113026/
https://ncbi.nlm.nih.gov/pubmed/18055696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1588507
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