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In situ hybridization at the electron microscope level: hybrid detection by autoradiography and colloidal gold

In situ hybridization has become a standard method for localizing DNA or RNA sequences in cytological preparations. We developed two methods to extend this technique to the transmission electron microscope level using mouse satellite DNA hybridization to whole mount metaphase chromosomes as the test...

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Detalhes bibliográficos
Main Authors: Hutchison, NJ, Langer-Safer, PR, Ward, DC, Hamkalo, BA
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1982
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2112979/
https://ncbi.nlm.nih.gov/pubmed/6183277
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