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DNA replication, chromatin structure, and histone phosphorylation altered by theophylline in synchronized HeLa S3 cells

The onset of DNA replication normally is coincident with an increase in histone 1 phosphorylation and a relaxation in chromatin structure. In this paper we show that 5 mM theophylline, added 2 h after selective detachment to synchronized HeLa-S-3 cells, delays the onset and reduces the rate of DNA s...

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Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 1981
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111767/
https://ncbi.nlm.nih.gov/pubmed/7228902
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