Mismatch repair deficiency associated with overexpression of the MSH3 gene

We tested the ability of recombinant hMutSα (hMSH2/hMSH6) and hMutSβ (hMSH2/hMSH3) heterodimers to complement the mismatch repair defect of HEC59, a human cancer cell line whose extracts lack all three MutS homologues. Although repair of both base/base mispairs and insertion–deletion loops was resto...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Marra, Giancarlo, Iaccarino, Ingram, Lettieri, Teresa, Roscilli, Giuseppe, Delmastro, Paola, Jiricny, Josef
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1998
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21116/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671718/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8568
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