Mismatch repair deficiency associated with overexpression of the MSH3 gene

We tested the ability of recombinant hMutSα (hMSH2/hMSH6) and hMutSβ (hMSH2/hMSH3) heterodimers to complement the mismatch repair defect of HEC59, a human cancer cell line whose extracts lack all three MutS homologues. Although repair of both base/base mispairs and insertion–deletion loops was resto...

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Autores principales: Marra, Giancarlo, Iaccarino, Ingram, Lettieri, Teresa, Roscilli, Giuseppe, Delmastro, Paola, Jiricny, Josef
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC21116/
https://ncbi.nlm.nih.gov/pubmed/9671718
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