Homeostatic Control of the Crypt-Villus Axis by the Bacterial Enterotoxin Receptor Guanylyl Cyclase C Restricts the Proliferating Compartment in Intestine

Guanylyl cyclase C (GC-C), the receptor for diarrheagenic enterotoxins and the paracrine ligands guanylin and uroguanylin, regulates intestinal secretion. Beyond volume homeostasis, its importance in modulating cancer cell proliferation and its uniform dysregulation early in colon carcinogenesis, re...

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Bibliografiske detaljer
Main Authors: Li, Peng, Lin, Jieru E., Chervoneva, Inna, Schulz, Stephanie, Waldman, Scott A., Pitari, Giovanni M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2007
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111108/
https://ncbi.nlm.nih.gov/pubmed/17974601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070198
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