Safety-modified episomal vectors for human gene therapy

The effectiveness of ongoing gene therapy trials may be limited by the expression characteristics of viral and plasmid-based vectors. To enhance levels of heterologous gene expression, we have developed a safety-modified episomal expression vector that replicates extrachromosomally in human cells. T...

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Detalhes bibliográficos
Main Authors: Cooper, Mark J., Lippa, Mara, Payne, Jennifer M., Hatzivassiliou, Georgia, Reifenberg, Erica, Fayazi, Behnaz, Perales, Jose C., Morrison, Laura J., Templeton, Dennis, Piekarz, Richard L., Tan, June
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21070/
https://ncbi.nlm.nih.gov/pubmed/9177238
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