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Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes

A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovered areas around developmental regulatory genes in which an insertion results in the same glo...

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Autors principals: Kikuta, Hiroshi, Fredman, David, Rinkwitz, Silke, Lenhard, Boris, Becker, Thomas S
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2106839/
https://ncbi.nlm.nih.gov/pubmed/18047696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-s1-s4
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