Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates

We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their developmental regulatory target genes, and phylogen...

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Detalhes bibliográficos
Main Authors: Kikuta, Hiroshi, Laplante, Mary, Navratilova, Pavla, Komisarczuk, Anna Z., Engström, Pär G., Fredman, David, Akalin, Altuna, Caccamo, Mario, Sealy, Ian, Howe, Kerstin, Ghislain, Julien, Pezeron, Guillaume, Mourrain, Philippe, Ellingsen, Staale, Oates, Andrew C., Thisse, Christine, Thisse, Bernard, Foucher, Isabelle, Adolf, Birgit, Geling, Andrea, Lenhard, Boris, Becker, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855176/
https://ncbi.nlm.nih.gov/pubmed/17387144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.6086307
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