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Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains

The chemokine receptor CXCR4 functions as a fusion coreceptor for T cell tropic and dual-tropic HIV-1 strains. To identify regions of CXCR4 that are important for coreceptor function, CXCR4–CXCR2 receptor chimeras were tested for the ability to support HIV-1 envelope (env) protein-mediated membrane...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Lu, Zhao-hai, Berson, Joanne F., Chen, Ying-hua, Turner, Julie D., Zhang, Tian-yuan, Sharron, Matthew, Jenks, M. Harley, Wang, Zi-xuan, Kim, Jin, Rucker, Joseph, Hoxie, James A., Peiper, Stephen C., Doms, Robert W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21066/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9177234/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.12.6426
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