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The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias
Huntington's disease and several of the spinocerebellar ataxias are caused by the abnormal expansion of a CAG repeat within the coding region of the disease gene. This results in the production of a mutant protein with an abnormally expanded polyglutamine tract. Although these disorders have a...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2106366/ https://ncbi.nlm.nih.gov/pubmed/18047739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-8-S1-S2 |
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