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Electrostatic Contributions to the Stability of the GCN4 Leucine Zipper Structure

Ion pairs are ubiquitous in X-ray structures of coiled coils, and mutagenesis of charged residues can result in large stability losses. By contrast, pK(a) values determined by NMR in solution often predict only small contributions to stability from charge interactions. To help reconcile these result...

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書誌詳細
主要な著者: Matousek, William M., Ciani, Barbara, Fitch, Carolyn A., Bertrand García-Moreno, E., Kammerer, Richard A., Alexandrescu, Andrei T.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2105789/
https://ncbi.nlm.nih.gov/pubmed/17920624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.09.007
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