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Electrostatic Contributions to the Stability of the GCN4 Leucine Zipper Structure

Ion pairs are ubiquitous in X-ray structures of coiled coils, and mutagenesis of charged residues can result in large stability losses. By contrast, pK(a) values determined by NMR in solution often predict only small contributions to stability from charge interactions. To help reconcile these result...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Matousek, William M., Ciani, Barbara, Fitch, Carolyn A., Bertrand García-Moreno, E., Kammerer, Richard A., Alexandrescu, Andrei T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2105789/
https://ncbi.nlm.nih.gov/pubmed/17920624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.09.007
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