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Sciatic Nerve Ligation-Induced Proliferation of Spinal Cord Astrocytes Is Mediated by κ Opioid Activation of p38 Mitogen-Activated Protein Kinase

Partial sciatic nerve ligation (pSNL) markedly increased glial fibrillary acidic protein immunoreactivity (GFAP-IR) 1 week after lesion in the L4–L5 spinal dorsal horn of wild-type, but not in dynorphin knock-out, mice lacking κ opioid receptors (KOR(−/−)) or in wild-type mice pretreated with the KO...

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Autors principals: Xu, Mei, Bruchas, Michael R., Ippolito, Danielle L., Gendron, Louis, Chavkin, Charles
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104780/
https://ncbi.nlm.nih.gov/pubmed/17344394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3728-06.2007
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