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κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses

Previous studies have demonstrated that stress may increase prodynorphin gene expression, and κ opioid agonists suppress drug reward. Therefore, we tested the hypothesis that stress-induced release of endogenous dynorphin may mediate behavioral responses to stress and oppose the rewarding effects of...

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Detalhes bibliográficos
Main Authors: McLaughlin, Jay P., Marton-Popovici, Monica, Chavkin, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104777/
https://ncbi.nlm.nih.gov/pubmed/12843270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-13-05674.2003
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