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THE TRITOPE MODEL FOR RESTRICTIVE RECOGNITION OF ANTIGEN BY T-CELLS: II. IMPLICATIONS FOR ONTOGENY, EVOLUTION AND PHYSIOLOGY
Based on the Tritope model of the TCR (Cohn, 2005c), a set of functional and evolutionary problems surrounding restrictive recognition of antigen are discussed. These include the origin of allele-specific recognition, the selection pressures for polygeneism and polymorphism, the TCR signaling intera...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2104471/ https://ncbi.nlm.nih.gov/pubmed/17889366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2006.02.033 |
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