ERK activation causes epilepsy by stimulating NMDA receptor activity

The ERK MAPK signalling pathway is a highly conserved kinase cascade linking transmembrane receptors to downstream effector mechanisms. To investigate the function of ERK in neurons, a constitutively active form of MEK1 (caMEK1) was conditionally expressed in the murine brain, which resulted in ERK...

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Autors principals: Nateri, Abdolrahman S, Raivich, Gennadij, Gebhardt, Christine, Da Costa, Clive, Naumann, Heike, Vreugdenhil, Martin, Makwana, Milan, Brandner, Sebastian, Adams, Ralf H, Jefferys, John G R, Kann, Oliver, Behrens, Axel
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099472/
https://ncbi.nlm.nih.gov/pubmed/17972914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601911
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