Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP

Association of PKA with the AMPA receptor GluR1 subunit via the A kinase anchor protein AKAP150 is crucial for GluR1 phosphorylation. Mutating the AKAP150 gene to specifically prevent PKA binding reduced PKA within postsynaptic densities (>70%). It abolished hippocampal LTP in 7–12 but not 4-week...

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Huvudupphovsmän: Lu, Yuan, Allen, Margaret, Halt, Amy R, Weisenhaus, Michael, Dallapiazza, Robert F, Hall, Duane D, Usachev, Yuriy M, McKnight, G Stanley, Hell, Johannes W
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099463/
https://ncbi.nlm.nih.gov/pubmed/17972919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601884
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