In Vivo Destabilization and Functional Defects of the Xeroderma Pigmentosum C Protein Caused by a Pathogenic Missense Mutation

Xeroderma pigmentosum group C (XPC) protein plays an essential role in DNA damage recognition in mammalian global genome nucleotide excision repair (NER). Here, we analyze the functional basis of NER inactivation caused by a single amino acid substitution (Trp to Ser at position 690) in XPC, previou...

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Bibliografiske detaljer
Main Authors: Yasuda, Gentaro, Nishi, Ryotaro, Watanabe, Eriko, Mori, Toshio, Iwai, Shigenori, Orioli, Donata, Stefanini, Miria, Hanaoka, Fumio, Sugasawa, Kaoru
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099227/
https://ncbi.nlm.nih.gov/pubmed/17682058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02166-06
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