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MafA Stability in Pancreatic β Cells Is Regulated by Glucose and Is Dependent on Its Constitutive Phosphorylation at Multiple Sites by Glycogen Synthase Kinase 3
Regulation of insulin gene expression by glucose in pancreatic β cells is largely dependent on a cis-regulatory element, termed RIPE3b/C1, in the insulin gene promoter. MafA, a member of the Maf family of basic leucine zipper (bZip) proteins, is a β-cell-specific transcriptional activator that binds...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2099218/ https://ncbi.nlm.nih.gov/pubmed/17682063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01573-06 |
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