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Speeding the Recovery from Ultraslow Inactivation of Voltage-Gated Na(+) Channels by Metal Ion Binding to the Selectivity Filter: A Foot-on-the-Door?
Slow inactivated states in voltage-gated ion channels can be modulated by binding molecules both to the outside and to the inside of the pore. Thus, external K(+) inhibits C-type inactivation in Shaker K(+) channels by a “foot-in-the-door” mechanism. Here, we explore the modulation of a very long-li...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Biophysical Society
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2098733/ https://ncbi.nlm.nih.gov/pubmed/17720727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.104794 |
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