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Speeding the Recovery from Ultraslow Inactivation of Voltage-Gated Na(+) Channels by Metal Ion Binding to the Selectivity Filter: A Foot-on-the-Door?

Slow inactivated states in voltage-gated ion channels can be modulated by binding molecules both to the outside and to the inside of the pore. Thus, external K(+) inhibits C-type inactivation in Shaker K(+) channels by a “foot-in-the-door” mechanism. Here, we explore the modulation of a very long-li...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Szendroedi, Julia, Sandtner, Walter, Zarrabi, Touran, Zebedin, Eva, Hilber, Karlheinz, Dudley, Samuel C., Fozzard, Harry A., Todt, Hannes
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2098733/
https://ncbi.nlm.nih.gov/pubmed/17720727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.104794
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