Reversal of anticancer multidrug resistance by the ardeemins

Two “reverse prenyl” hexahydropyrroloindole alkaloids, 5-N-acetylardeemin and 5-N-acetyl-8-demethylardeemin, were evaluated as reversal agents in cells exhibiting a multidrug resistant (MDR) phenotype. These ardeemins (i) reversed drug resistance to vinblastine (VBL) or to taxol as much as 700-fold...

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Detalhes bibliográficos
Main Authors: Chou, Ting-Chao, Depew, Kristopher M., Zheng, Yu-Huang, Safer, Michelle L., Chan, Daniel, Helfrich, Barbara, Zatorska, Danuta, Zatorski, Andrzej, Bornmann, William, Danishefsky, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20982/
https://ncbi.nlm.nih.gov/pubmed/9653193
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