Guanosine stimulates neurite outgrowth in PC12 cells via activation of heme oxygenase and cyclic GMP

Undifferentiated rat pheochromocytoma (PC12) cells extend neurites when cultured in the presence of nerve growth factor (NGF). Extracellular guanosine synergistically enhances NGF-dependent neurite outgrowth. We investigated the mechanism by which guanosine enhances NGF-dependent neurite outgrowth....

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Main Authors: Bau, Christian, Middlemiss, Pamela J., Hindley, Shaun, Jiang, Shucui, Ciccarelli, Renata, Caciagli, Francesco, DiIorio, Patrizia, Werstiuk, Eva S., Rathbone, Michel P.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2005
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096532/
https://ncbi.nlm.nih.gov/pubmed/18404501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-005-6214-0
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