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Structural reengineering of imatinib to decrease cardiac risk in cancer therapy

Imatinib, a selective, small-molecule tyrosine kinase inhibitor, has life-saving clinical activity in certain cancers, but questions have been raised about the potential for cardiac toxicity through inhibition of its target, ABL kinase. In this issue of the JCI, Fernández et al. describe a novel met...

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Sonraí Bibleagrafaíochta
Príomhúdar: Demetri, George D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096446/
https://ncbi.nlm.nih.gov/pubmed/18060025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34252
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