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Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice
To study the role of the interferon- (IFN) γR2 chain in IFN-γ signaling and immune function, IFN-γR2-deficient mice have been generated and characterized. Cells derived from IFN-γR2 −/− mice are unable to activate either JAK/STAT signaling proteins or gene transcription in response to IFN-γ. The lac...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC20959/ https://ncbi.nlm.nih.gov/pubmed/9653170 |
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