Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice

To study the role of the interferon- (IFN) γR2 chain in IFN-γ signaling and immune function, IFN-γR2-deficient mice have been generated and characterized. Cells derived from IFN-γR2 −/− mice are unable to activate either JAK/STAT signaling proteins or gene transcription in response to IFN-γ. The lac...

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Bibliographic Details
Main Authors: Lu, Binfeng, Ebensperger, Christoph, Dembic, Zlatko, Wang, Yulin, Kvatyuk, Marina, Lu, Tianhong, Coffman, Robert L., Pestka, Sidney, Rothman, Paul B.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC20959/
https://ncbi.nlm.nih.gov/pubmed/9653170
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