Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype‐low (CIMP‐low) in colorectal cancer

BACKGROUND: The CpG island methylator phenotype (CIMP or CIMP‐high) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer. In contrast, a phenotype with less widespread promoter methylation (CIMP‐low) has not been well characterised. O‐6‐methylguanine‐DNA methy...

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Detalhes bibliográficos
Main Authors: Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J, Suemoto, Yuko, Meyerhardt, Jeffrey A, Fuchs, Charles S
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Colorectal Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095664/
https://ncbi.nlm.nih.gov/pubmed/17339237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2007.119750
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