Rats and mice immunised with chimeric human/mouse proteinase 3 produce autoantibodies to mouse Pr3 and rat granulocytes

AIM: In this study, we employed chimeric human/mouse Proteinase 3 (PR3) proteins as tools to induce an autoantibody response to PR3 in rats and mice. METHOD: Rats and mice were immunised with recombinant human PR3 (HPR3), recombinant murine PR3 (mPR3), single chimeric human/mouse PR3 (HHm, HmH, mHH,...

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Detalhes bibliográficos
Main Authors: van der Geld, Ymke M, Hellmark, Thomas, Selga, Daina, Heeringa, Peter, Huitema, Minke G, Limburg, Pieter C, Kallenberg, Cees G M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Concise Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095322/
https://ncbi.nlm.nih.gov/pubmed/17644551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2006.064626
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