Atrial tachycardia induces remodelling of muscarinic receptors and their coupled potassium currents in canine left atrial and pulmonary vein cardiomyocytes

BACKGROUND AND PURPOSE: Both parasympathetic tone and atrial tachycardia (AT) remodelling of ion channels play important roles in atrial fibrillation (AF) pathophysiology. Different muscarinic cholinergic receptor (mAChR) subtypes (M(2), M(3), M(4)) in atrial cardiomyocytes are coupled to distinct K...

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Autors principals: Yeh, Y-H, Qi, X, Shiroshita-Takeshita, A, Liu, J, Maguy, A, Chartier, D, Hebert, T, Wang, Z, Nattel, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095106/
https://ncbi.nlm.nih.gov/pubmed/17618308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707376
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