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Inter-conversion of Neuregulin2 full and partial agonists for ErbB4
The EGF family hormone NRG2β potently stimulates ErbB4 tyrosine phosphorylation and coupling to IL3 independence. In contrast, the NRG2α splicing isoform has lower affinity for ErbB4, does not potently stimulate ErbB4 phosphorylation, and fails to stimulate ErbB4 coupling. Here we investigate these...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2094732/ https://ncbi.nlm.nih.gov/pubmed/17945187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.10.004 |
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