Insights From Atomic-Resolution X-Ray Structures Of Chemically-Synthesized Hiv-1 Protease In Complex With Inhibitors

The HIV-1 protease is an aspartyl protease essential for HIV-1 viral infectivity. HIV-1 protease has one catalytic site formed by the homodimeric enzyme. We have chemically synthesized fully active HIV-1 protease using modern ligation methods. When complexed with the classic substrate-derived inhibi...

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Autors principals: Johnson, Erik C.B., Malito, Enrico, Shen, Yuequan, Pentelute, Brad, Rich, Dan, Florián, Jan, Tang, Wei-Jen, Kent, Stephen B.H.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094697/
https://ncbi.nlm.nih.gov/pubmed/17869270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.07.054
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