Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis

Intra-acinar cell activation of digestive enzyme zymogens including trypsinogen is generally believed to be an early and critical event in acute pancreatitis. We have found that the phosphatidylinositol 3-kinase inhibitor wortmannin can reduce the intrapancreatic activation of trypsinogen that occur...

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Hauptverfasser: Singh, Vijay P., Saluja, Ashok K., Bhagat, Lakshmi, van Acker, Gijs J.D., Song, Albert M., Soltoff, Stephen P., Cantley, Lewis C., Steer, Michael L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209439/
https://ncbi.nlm.nih.gov/pubmed/11696584
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